Anti Estrogen
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The Most Popular Anti-Estrogens
Selective Estrogen Receptor Modulators (SERMs) and Aromatase Inhibitors (AIs) are two categories of medications commonly used in bodybuilding during and after a cycle of anabolic steroids. Sometimes, even experienced athletes tend to confuse these two types of anti-estrogen drugs. In the most general sense, the main difference between them is that SERMs are used in most cases – during a steroid cycle and after it in PCT (post-cycle therapy), while AIs are generally used exclusively during the steroid cycle itself, to solve quite specific problems.
The most common aromatase inhibitors (estrogen blockers) are:
Their functional purpose in bodybuilding is to prevent and treat the first signs of gynecomastia and other estrogen-related complications (fluid accumulation, increased pressure), which, are very effective in the case of the use of aromatizing steroids (Testosterones, Methandienone and others). AIs are never really used for post-cycle therapy purposes.
The best anti-estrogens for PCT are:
They, in contrast to aromatase inhibitors, are almost never used during the cycle. The most optimal solution would be their use for post-cycle therapy, since they contribute to the restoration of the secretion of testosterone suppressed by steroids in the athlete’s body, while having anti-estrogenic effects.
How are both drug groups used?
AIs
AIs are used directly during the steroid cycle, when the athlete takes steroids that are prone to convert into estrogens. These are usually all types of Testosterone esters, Methandienone and others. Usually, the need for them is determined by taking tests for the level of estradiol, after which the very need and dosage for their prophylactic intake is determined. Often, the prophylactic intake of Anastrozole and Letrozole on the cycle is carried out in dosages of 0.25-0.5mg every 3-4 days, starting from the first or second week of the cycle and ending after all steroids are removed from the body. Exemestane is used with the same frequency, but in dosages of 12-25mg. So, in the case of “short” drugs, such as Methandienone, the intake of AI should be completed immediately after taking the last pill, and in the case of “long” steroids (for example, Testosterone Enanthate or Sustanon), the intake of aromatase blockers is required 2 more weeks after the final injections until the AAC is eliminated from the body. In the case when the first signs of gynecomastia have already manifested themselves, the AI should be taken as follows: Anastrozole (1 mg daily), Letrozole (2.5 mg daily) and Exemestane (25 mg daily) – until the symptoms are eliminated, after which the dosage should be reduced to the minimum … It should be noted that in especially advanced cases, even such strong drugs may be useless.
SERMs
The purpose of SERMs, as already noted, is the restoration of the natural secretion of the athlete’s own testosterone after the steroid cycle, which is suppressed because of the use of AAS. These interventions are generally referred to as “post cycle therapy” or “PCT”. Tamoxifen dosages can vary between 10-30 milligrams per day, while the Clomid dosage range is between 25-100 milligrams per day, and they can vary over the period of PCT (for example, from the highest dosages at the start and to the minimum – at the end). This largely depends on how long, in what doses and how many anabolic steroids were used during the cycle. The duration of PCT can be from 2 to 4 weeks. Separately, it should be noted that Tamoxifen is never used for post-cycle therapy after the use of progestin steroids: Nandrolone, Trenbolone and Oxymetholone as this can provoke unwanted side effects. In these cases, Clomid is always taken.
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